Last edited by Vilar
Monday, May 11, 2020 | History

4 edition of Cellular Interactions With Extracellular Matrix During Development & in Muscle Disease found in the catalog.

Cellular Interactions With Extracellular Matrix During Development & in Muscle Disease

Carl-Fredrik Tiger

Cellular Interactions With Extracellular Matrix During Development & in Muscle Disease

by Carl-Fredrik Tiger

  • 284 Want to read
  • 18 Currently reading

Published by Uppsala Universitet .
Written in English

    Subjects:
  • Life Sciences - Biology - Molecular Biology,
  • Science,
  • Science/Mathematics

  • Edition Notes

    SeriesComprehensive Summaries of Uppsala Dissertations from the Faculty Science and Technology, 720
    The Physical Object
    FormatPaperback
    Number of Pages39
    ID Numbers
    Open LibraryOL12854533M
    ISBN 109155453287
    ISBN 109789155453282
    OCLC/WorldCa186003407

    The periodontal ligament (PDL) is a highly vascularized connective tissue surrounding the root of a tooth. In particular, the PDL is continuously exposed to mechanical stresses during the phases of mastication, and it provides physical, sensory, and trophic functions. It is known that the application of orthodontic force creates a change in periodontal structures. In fact, these forces. The extracellular matrix (ECM) is the non-cellular component present within all tissues and organs, and provides not only essential physical scaffolding for the cellular constituents but also initiates crucial biochemical and biomechanical cues that are required for tissue morphogenesis, differentiation and .

    In biology, the extracellular matrix (ECM) is a three-dimensional network of extracellular macromolecules, such as collagen, enzymes, and glycoproteins, that provide structural and biochemical support to surrounding cells. Because multicellularity evolved independently in different multicellular lineages, the composition of ECM varies between multicellular structures; however, cell adhesion.   Vascular extracellular matrix in normal vessels. Normal blood vessel walls are composed of endothelial cells, SMC (smooth muscle cells), and ECM (the extracellular matrix) that vary within the different layers of the vessel wall (reviewed in Wight ).They are arranged in concentric layers: the intima, composed of the lining endothelial cells with minimal subendothelial ECM enriched in Cited by:

    The mechanism that causes the Alzheimer’s disease (AD) pathologies, including amyloid plaque, neurofibrillary tangles, and neuron death, is not well understood due to the lack of robust study models for human brain. Three-dimensional organoid systems based on human pluripotent stem cells (hPSCs) have shown a promising potential to model neurodegenerative diseases, including AD. Tendons and ligaments are extracellular matrix (ECM)-rich structures that interconnect muscles and bones. Recent work has shown how tendon fibroblasts (tenocytes) interact with muscles via the ECM to establish connectivity and strengthen attachments under tension. Similarly, ECM-dependent interactions between tenocytes and cartilage/bone ensure that tendon-bone attachments form with the.


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Cellular Interactions With Extracellular Matrix During Development & in Muscle Disease by Carl-Fredrik Tiger Download PDF EPUB FB2

Cardiac morphogenesis is dependent on the coordinated and programmed expression of cell surface receptors that can mediate interactions of cells with extracellular matrix (ECM) components, which in turn promote either cell adhesion or migration and determine the : Jane-Lyse Samuel, Philippe Ratajczak, Lydie Rappaport.

as matrix structure and function, cell attachment, and cell surface proteins mediating cell–matrix interactions, synthesis, regulation, composition, structure, assembly, remodeling, and function of the matrix are covered.

A common thread uniting the topics is the essential nature that the matrix plays in normal development and by: 1. Extracellular Matrix in Development and Disease Julia Thom Oxford 1,2,3,4, *, Jonathon C.

Reeck 1,2 and Makenna J. Hardy 1,3 1 Center of Biomedical Research Excellence in Matrix Biology, Boise State University, Boise, ID The cell-matrix interactions are crucial for normal biological processes and when disrupted they may lead to pathological processes.

In particular, the biological importance of ECM-cell membrane-cytoskeleton interactions in skeletal muscle is accentuated by the number of inherited muscle diseases caused by mutations in proteins conferring these by: The formation and maintenance of tissues in multicellular animals are crucially dependent on cellular interactions with the extracellular matrix (ECM).

Two different studies on such interactions are presented herein. Studies on expression of laminins in normal and dystrophic skeletal muscle, clarified a much debated issue regarding discrepancies seen for laminin α1-chain expression between Cited by: 1.

Abstract. The extracellular matrix (ECM) of the heart is intimately associated with cardiac function in development and disease. The heart ECM is composed of the interstitial collagens, including predominantly type I and type III collagen, various proteoglycans and noncollagenous glycoproteins such as laminin and fibronectin [2, 7, 22].

Introduction. The idea of a special issue on cell interactions with the extracellular matrix (ECM) is a result of the increasing awareness about the integral functions of the ECM in virtually all dynamic processes of development, maintenance, reconstruction and disease. The purpose of this special issue is not to present a comprehensive overview of all macromolecules that form the ECM and their interacting cellular.

The idea of a special issue on cell interactions with the extracellular matrix (ECM) is a result of the increasing awareness about the integral functions of the ECM in virtually all dynamic processes of development, mainte-nance, reconstruction and disease. The purpose of this special issue is not to present a comprehensive overview of.

Extracellular matrix in development and disease. This Special Issue will deal with molecular and cellular aspects of the role of extracellular matrix in development and disease.

Cells exist in three-dimensional scaffolding called the extracellular matrix. The matrix holds together the millions of cells that make up our blood vessels, organs, skin, and all tissues of the body. Coronary vessels are formed with the cells originating mostly from extracardiac tissue known as the proepicardial organ (PE) (see [] for review).During coronary development, strong expression of TNC is observed, closely associated with thickening of the medial layer when the primitive coronary vasculature connects with the aortic sinuses [], suggesting a significant role of TNC in.

Jeffrey A. Hubbell, in Principles of Tissue Engineering (Fourth Edition), Abstract. The extracellular matrix is a complex chemically and physically crosslinked network of proteins and glycosaminoglycans.

This matrix serves to organize cells in space, to provide them with environmental signals to direct site-specific cellular regulation and to separate one tissue space from another. Thus, smooth muscle cell intrinsic controlling mechanisms may support a cell autonomous direction of differentiation.

On the other hand, during development and in disease the cell intrinsic program can be modulated by extrinsic factors, including direct cell-cell interactions, cell-extracellular matrix interactions, and diffusing soluble. Extracellular Matrix in Development and Disease.

cell attachment, and cell surface proteins mediating cell–matrix interactions, synthesis, regulation, composition, structure, assembly, remodeling, and function of the matrix are covered.

Versican may serve as a therapeutic target to promote myoblast fusion during muscle development Cited by: 1. Cell-Cell Interactions.

Direct interactions between cells, as well as between cells and the extracellular matrix, are critical to the development and function of multicellular organisms.

Some cell-cell interactions are transient, such as the interactions between cells of the immune system and the interactions that direct white blood cells to sites of tissue inflammation. Extracellular matrix remodelling during intestinal development.

a | Tadpole-to-adult intestinal epithelium remodelling during Xenopus laevis morphogenesis. In the pre-metamorphosis tadpole, the small intestine consists of a single layer of larval epithelium (also known as typhlosole), connective tissue and a thin muscle by: Download Citation | Extracellular Matrix in Development | Cells in the developing embryo depend on signals from the extracellular environment to help guide their differentiation.

An important. The extracellular matrix occupies approximately 20% of the normal adult brain 59 and is composed of mainly unbranched polysaccharide hyaluronic acid and chondroitin sulfate proteoglycans of the lectican family, such as aggrecan, versican, brevican, and neurocan, 60 where hyaluronic acid acts as a backbone to recruit proteoglycans and glycoproteins into extracellular matrix structures.

61–63 In addition, a variety of other glycoproteins and proteoglycans contribute to extracellular matrix. An important mediator in this process is the extracellular matrix – secreted macromolecules that interact to form large protein networks outside the cell.

During development, the extracellular. Second, that there is not a “synthetic” versus “contractile” phenotype, but rather, there is a gradual increase in the amount of morphologically recognizable structures associated with a contractile smooth muscle cell.

During the earlier phases of prenatal development, highly biosynthetic smooth muscle cells are observed to also accumulate myofilaments and are elastogenic. Cellular Interactions with Extracellular Matrix During Development and in Muscle Disease Tiger, Carl-Fredrik Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Faculty of Science and Technology, Biology, Department of Cell and Molecular Biology.

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For further information, including about cookie.Skeletal muscle tissue makes up approximately 40% of the total body mass in adult mammals. Contractile muscle fibers building skeletal muscle tissue are coated by an extracellular matrix .In considering this paradox, it should be kept in mind that interactions between myoblasts/myocytes and the extracellular matrix play a crucial role in skeletal muscle development (for reviews see.